abstract：PURPOSE:(11)C-PK11195 is a radiopharmaceutical for in vivo assessment of peripheral benzodiazepine receptor (PBR) activity using PET. We sought to clarify the metabolic fate of (11)C-PK11195 in a test-retest setting using radio-HPLC in comparison with radio-TLC, and the whole-body distribution in humans. MATERIALS AND...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Roivainen A,Någren K,Hirvonen J,Oikonen V,Virsu P,Tolvanen T,Rinne JO

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:To characterise tissue sites of immune activation and HIV replication we performed FDG-PET in ART-treated and ART-naive HIV-infected individuals. Specific aims were to establish whether HIV-infected patients can be differentiated on the basis of the detection of specific locations of viral replication, even in ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Lucignani G,Orunesu E,Cesari M,Marzo K,Pacei M,Bechi G,Gori A,Gaito S,Clerici M,Chiti A

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:Positron emission tomography (PET) was evaluated in low-grade non-Hodgkin lymphoma (NHL) to determine its impact on staging and management and to compare PET and gallium scans. METHODS:PET resulted in management plan changes in 74 patients with untreated low-grade NHL stages I to III. Patient outcomes to 12 mo...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Scott AM,Gunawardana DH,Wong J,Kirkwood I,Hicks RJ,Ho Shon I,Ramshaw JE,Robins P

更新日期：2009-03-01 00:00:00

abstract：INTRODUCTION:Positron emission tomography (PET) is a fully quantitative technology for imaging metabolic pathways and dynamic processes in vivo. Attenuation correction of raw PET data is a prerequisite for quantification and is typically based on separate transmission measurements. In PET/CT attenuation correction, how...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Hofmann M,Pichler B,Schölkopf B,Beyer T

更新日期：2009-03-01 00:00:00

abstract：INTRODUCTION:Hybrid imaging is now widely accepted in cancer imaging with increasing use of PET/CT in clinical practice. The advantages of MRI compared to CT with respect to radiation exposure and soft-tissue lesion contrast, as well as the possibility of performing more sophisticated assessment of tissue chemistry, ha...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Hicks RJ,Lau EW

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:Depression is a common symptom in patients suffering from Parkinson's disease (PD) and markedly reduces their quality of life. As post-mortem studies have shown, its presence may reflect extensive cell loss in the midbrain and brainstem with imbalances in monoaminergic neurotransmitters. However, in vivo eviden...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Hesse S,Meyer PM,Strecker K,Barthel H,Wegner F,Oehlwein C,Isaias IU,Schwarz J,Sabri O

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:Diffusion-weighted magnetic resonance imaging (DWI) and fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) are oncological feasible techniques. Currently, apparent diffusion coefficient (ADC) measured by DWI and standard uptake value (SUV) from FDG PET/CT have similar applications ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ho KC,Lin G,Wang JJ,Lai CH,Chang CJ,Yen TC

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:Functional brain (99m)Tc-HMPAO single-photon emission computed tomography (SPECT) is a useful diagnostic tool for assessment of regional cerebral blood flow, particularly in dementia, cerebrovascular disease and epilepsy. Currently, the European and American Association of Nuclear Medicine Procedure Guidelines ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Thomsen G,de Nijs R,Hogh-Rasmussen E,Frokjaer V,Svarer C,Knudsen GM

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:Firefly luciferase catalyzes the oxidative decarboxylation of D: -luciferin to oxyluciferin in the presence of cofactors, producing bioluminescence. This reaction is used in optical bioluminescence-based molecular imaging approaches to detect the expression of the firefly luciferase reporter gene. Biokinetics a...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Berger F,Paulmurugan R,Bhaumik S,Gambhir SS

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:Respiratory motion of lung lesions is a limiting factor of quantification of positron emission tomography (PET) data. As some important applications of PET such as therapy monitoring and radiation therapy treatment planning require precise quantification, it is necessary to correct PET data for motion artefacts...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Bundschuh RA,Martínez-Möller A,Essler M,Nekolla SG,Ziegler SI,Schwaiger M

更新日期：2008-11-01 00:00:00

abstract：INTRODUCTION:Bone pain is a common symptom of metastatic disease in cancer, experienced with various intensities by about 30% of cancer patients, during the development of their disease, up to 60-90% in the latest phases. DISCUSSION:In addition to other therapies, such as analgesics, bisphosphonates, chemotherapy, hor...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Bodei L,Lam M,Chiesa C,Flux G,Brans B,Chiti A,Giammarile F,European Association of Nuclear Medicine (EANM).

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:Lipid nanocapsules (LNC) entrapping lipophilic complexes of (188)Re ((188)Re(S(3)CPh)(2)(S(2)CPh) [(188)Re-SSS]) were investigated as a novel radiopharmaceutical carrier for internal radiation therapy of malignant gliomas. The present study was designed to evaluate the efficacy of intra-cerebral administration ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Allard E,Hindre F,Passirani C,Lemaire L,Lepareur N,Noiret N,Menei P,Benoit JP

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the influence of a computer-based decision support system (DSS) on performance and inter-observer variability of interpretations regarding ischaemia and infarction in myocardial perfusion scintigraphy (MPS). METHODS:Seven physicians independently interpreted 97 MPS stud...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Tägil K,Bondouy M,Chaborel JP,Djaballah W,Franken PR,Grandpierre S,Hesse B,Lomsky M,Marie PY,Poisson T,Edenbrandt L

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:To investigate whether (11)C-N-methylspiperone ((11)C-NMSP) microPET could be used for imaging neural stem cells (NSCs) transplantation in a rat model of traumatic brain injury. METHODS:NSCs were induced to express dopamine receptor type 2 (DRD(2)), then confirmed by RT-PCR, Western blotting and immunocytochem...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Zhang H,Zheng X,Yang X,Fang S,Shen G,Zhao C,Tian M

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:(18)F-8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine ((18)F-CPFPX) is a potent radioligand to study human cerebral A(1) adenosine receptors and their neuromodulatory and neuroprotective functions with positron emission tomography (PET). The purpose of this study was to determine the biodistribution and the r...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Herzog H,Elmenhorst D,Winz O,Bauer A

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:PET imaging has been recently introduced for investigating the type 1 angiotensin II receptor (AT(1)R) in vivo. The goal of the present study was to investigate the effects of acute and chronic exposure to angiotensin converting enzyme inhibitors (ACEI) on the AT(1)R in the dog kidney. METHODS:Animals were ima...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Zober TG,Fabucci ME,Zheng W,Brown PR,Seckin E,Mathews WB,Sandberg K,Szabo Z

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:Patients with persistent elevated PSA and repeated negative prostate biopsy, that means having the prostate biopsied at multiple times, were investigated with 18F-choline PET/CT to delineate prostate cancer and guide renewed prostate biopsy. METHODS:Twenty patients with elevated PSA and negative prostate biops...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Igerc I,Kohlfürst S,Gallowitsch HJ,Matschnig S,Kresnik E,Gomez-Segovia I,Lind P

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:(153)Sm-ethylenediaminetetramethylenephosphonic acid (EDTMP; Quadramet) is indicated for the treatment of painful bone metastases, whereas zoledronic acid (Zometa) is indicated for the prevention of skeletal complications. Because of the different therapeutic effects, combining the treatments may be beneficial....

journal_title：European journal of nuclear medicine and molecular imaging

authors： Lam MG,Dahmane A,Stevens WH,van Rijk PP,de Klerk JM,Zonnenberg BA

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:(131)Iodine metaiodobenzylguanidine ((131)I-MIBG) is a radiopharmaceutical used for scintigraphic localisation of phaeochromocytomas and paragangliomas. The experience with its therapeutic use is limited. We report our experience for the treatment of malignant phaeochromocytoma and paraganglioma. MATERIALS AND...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Gedik GK,Hoefnagel CA,Bais E,Olmos RA

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:This study focusses on a promising carrier system for therapeutic and imaging purposes using meso-tetrakis[3,4-bis(carboxymethyleneoxy)phenyl] porphyrin (T(3,4)CPP). To assess its potential for clinical use, we labelled T(3,4)CPP with (188)Re and analysed some kinetic biodistribution parameters after intravenou...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Jia ZY,Deng HF,Pu MF,Luo SZ

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:Functional activation protocols are widely applied for the study of brain-cognition relations. Only few take advantage of the intrinsic characteristics of SPECT, particularly those allowing cognitive assessment outside of the camera, in settings close to the standard clinical or laboratory ones. The purpose of ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ludwig C,Chicherio C,Terraneo L,Magistretti P,de Ribaupierre A,Slosman D

更新日期：2008-04-01 00:00:00

abstract：:Radionuclide imaging of cardiac function represents a number of well-validated techniques for accurate determination of right (RV) and left ventricular (LV) ejection fraction (EF) and LV volumes. These first European guidelines give recommendations for how and when to use first-pass and equilibrium radionuclide ventri...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Hesse B,Lindhardt TB,Acampa W,Anagnostopoulos C,Ballinger J,Bax JJ,Edenbrandt L,Flotats A,Germano G,Stopar TG,Franken P,Kelion A,Kjaer A,Le Guludec D,Ljungberg M,Maenhout AF,Marcassa C,Marving J,McKiddie F,Schaefer

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:High-energy gamma probes have recently become commercially available, developed for (18)F-FDG probe-guided surgery. The radiation received by the staff in the operating room might limit the use of it, but has never been determined. We therefore wanted to measure the absorbed staff doses at operations where pati...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Andersen PA,Chakera AH,Klausen TL,Binderup T,Grossjohann HS,Friis E,Palnaes Hansen C,Schmidt G,Kjaer A,Hesse B

更新日期：2008-03-01 00:00:00

abstract：AIM:This study assessed the ability of visual and quantitative 124-iodine positron emission tomography ((124)I PET) data to detect disseminated iodine-avid lung metastases (DILM) of differentiated thyroid cancer (DTC). MATERIALS AND METHODS:Using "post-therapy" 131-iodine ((131)I) whole-body scintigraphy (TxWBS) and t...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Freudenberg LS,Jentzen W,Müller SP,Bockisch A

更新日期：2008-03-01 00:00:00

abstract：:To study Alzheimer's disease (AD), a variety of mouse models has been generated through the overexpression of the amyloid precursor protein and/or the presenilins harboring one or several mutations found in familial AD. With aging, these mice develop several lesions similar to those of AD, including diffuse and neurit...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Radde R,Duma C,Goedert M,Jucker M

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:The nucleoside analog 3'-deoxy-3'-(18)F-fluorothymidine (FLT) has been introduced for imaging cell proliferation with positron emission tomography (PET). We prospectively compared the diagnostic efficacy of FLT PET with that of 2-deoxy-2-(18)F-fluoro-D-glucose (FDG) PET for the preoperative nodal and distant me...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Yamamoto Y,Nishiyama Y,Kimura N,Ishikawa S,Okuda M,Bandoh S,Kanaji N,Asakura M,Ohkawa M

更新日期：2008-02-01 00:00:00

abstract：PURPOSE:Radioligand binding studies show that beta(1)-adrenoceptor (beta(1)-AR) density may be reduced in heart disease without down regulation of beta(2)-ARs. Radioligands are available for measuring total beta-AR density non-invasively with clinical positron emission tomography (PET) but none are selective for beta(1...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Law MP,Wagner S,Kopka K,Pike VW,Schober O,Schäfers M

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:Neuroendocrine diseases are a heterogeneous group of entities with the ability to take up amine precursors, such as L-DOPA, and convert them into biogenic amines, such as dopamine. Congenital hyperinsulinism of infancy (HI) is a neuroendocrine disease secondary to either focal adenomatous hyperplasia or a diffu...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ribeiro MJ,Boddaert N,Bellanné-Chantelot C,Bourgeois S,Valayannopoulos V,Delzescaux T,Jaubert F,Nihoul-Fékété C,Brunelle F,De Lonlay P

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:The molecular imaging of tumour neoangiogenesis currently represents a major field of research for the diagnostic and treatment strategy of solid tumours. Endothelial cells from tumour neovessels overexpress the alpha(v)beta(3) integrin, which selectively binds to Arg-Gly-Asp (RGD)-containing peptides. We evalu...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sancey L,Ardisson V,Riou LM,Ahmadi M,Marti-Batlle D,Boturyn D,Dumy P,Fagret D,Ghezzi C,Vuillez JP

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:The aim of this study was to determine whether the follow-up of pain processing recovery in hyperalgesic fibromyalgia (FM) could be objectively evaluated with brain perfusion ethyl cysteinate dimer single photon computerized tomography (ECD-SPECT) after administration of ketamine. MATERIALS AND METHODS:We enro...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Guedj E,Cammilleri S,Colavolpe C,de Laforte C,Niboyet J,Mundler O

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:Myocardial perfusion with PET/CT has advantages over conventional SPECT. We describe our initial European experience using (82)Rubidium-PET/CT, as part of a clinical myocardial perfusion service. METHODS:We studied the first 100 patients (64 male; 36 female, mean age = 60: SD +/-12.5y, mean body mass index = 3...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Groves AM,Speechly-Dick ME,Dickson JC,Kayani I,Endozo R,Blanchard P,Shastry M,Prvulovich E,Waddington WA,Ben-Haim S,Bomanji JB,McEwan JR,Ell PJ

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the applicability of [(99m)Tc]Demotensin 5 and 6 [Formula: see text] in the targeted diagnostic imaging of neurotensin subtype 1 receptor (NTS1-R)-expressing tumours. METHODS:Labelling of Demotensin 5 and 6 with (99m)Tc was conducted by brief incubation with (99m)TcO(4) (-...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Maina T,Nikolopoulou A,Stathopoulou E,Galanis AS,Cordopatis P,Nock BA

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:Although( 18)F-fluorodeoxyglucose (FDG) PET is an established imaging technique to assess brain glucose utilisation, accurate measurement of tracer concentration is confounded by the presence of partial volume effect (PVE) due to the limited spatial resolution of PET, which is particularly true in atrophic brai...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Samuraki M,Matsunari I,Chen WP,Yajima K,Yanase D,Fujikawa A,Takeda N,Nishimura S,Matsuda H,Yamada M

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:The nucleoside analogue 3'-deoxy-3'-(18)F-fluorothymidine (FLT) has recently been introduced for imaging cell proliferation with positron emission tomography (PET). We prospectively evaluated whether FLT uptake reflects proliferative activity as indicated by the Ki-67 index in non-small cell lung cancer (NSCLC)...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Yamamoto Y,Nishiyama Y,Ishikawa S,Nakano J,Chang SS,Bandoh S,Kanaji N,Haba R,Kushida Y,Ohkawa M

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:Different attempts have been made to develop a suitable radioligand for targeting CCK-2 receptors in vivo, for staging of medullary thyroid carcinoma (MTC) and other receptor-expressing tumours. After initial successful clinical studies with [DTPA(0),D: Glu(1)]minigastrin (DTPA-MG0) radiolabelled with (111)In a...

journal_title：European journal of nuclear medicine and molecular imaging

authors： von Guggenberg E,Dietrich H,Skvortsova I,Gabriel M,Virgolini IJ,Decristoforo C

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:It has been shown that some primary human tumours and their metastases, including prostate and breast tumours, overexpress gastrin-releasing peptide (GRP) receptors. Bombesin (BN) is a neuropeptide with a high affinity for these GRP receptors. We demonstrated successful scintigraphic visualisation of BN recepto...

journal_title：European journal of nuclear medicine and molecular imaging

authors： de Visser M,Bernard HF,Erion JL,Schmidt MA,Srinivasan A,Waser B,Reubi JC,Krenning EP,de Jong M

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:Previous functional neuroimaging studies suggest that selective aspects of the brain serotonin (5-HT) system change during the aging process. Here, we assessed the effects of aging on the brain regional alpha-[(11)C]methyl-L: -tryptophan (alpha-[(11)C]MTrp) trapping rate constant (K*; microl.g(-1).min(-1)), whi...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Rosa-Neto P,Benkelfat C,Sakai Y,Leyton M,Morais JA,Diksic M

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Bone metastases are responsible for most of the morbidity associated with hormone-refractory prostate cancer (HRPC). 153Sm-ethylenediaminetetramethylene phosphonate (153Sm-EDTMP) has been approved for palliation of painful skeletal metastases. We retrospectively investigated the possible synergistic effect o...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ricci S,Boni G,Pastina I,Genovesi D,Cianci C,Chiacchio S,Orlandini C,Grosso M,Alsharif A,Chioni A,Di Donato S,Francesca F,Selli C,Rubello D,Mariani G

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:Using 123I for diagnostic purposes avoids the risk of stunning for subsequent radioiodine treatment and affords an excellent image quality. In this study we assessed the role of 123I in comparison with 131I post-treatment imaging in patients with thyroid cancer. METHODS:We compared a total of 292 123I scans wi...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Urhan M,Dadparvar S,Mavi A,Houseni M,Chamroonrat W,Alavi A,Mandel SJ

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:It is a matter of controversy whether prophylactic lymph node dissection improves prognosis and survival in papillary thyroid carcinoma (PTC) patients without suspicion of lymph node metastases either clinically or on ultrasonography. It is possible that in such patients the use of lymphatic mapping and sentine...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Pelizzo MR,Rubello D,Boschin IM,Piotto A,Paggetta C,Toniato A,De Salvo GL,Giuliano A,Mariani G,Casara D

更新日期：2007-06-01 00:00:00